Table A1. Antimicrobial drug susceptibility profiles of CV isolates compared with Mycobacterium chelonae, M. massiliense, and M. abscessus isolates*.
Antimicrobial drug |
M. abscessus, n = 41 |
|
M. massiliense, n = 5 |
|
M. chelonae, n = 58 |
|
CV, n = 25 |
||||||||||||
Range |
S, % |
I, % |
R, % |
Range |
S, % |
I, % |
R, % |
Range |
S, % |
I , % |
R, % |
Range |
S, % |
I, % |
R, % |
||||
Amikacin | 8−32 | 73.2 | 26.8 | 0.0 | 8−32 | 60.0 | 40.0 | 0.0 | 8−>256 | 32.8 | 51.7 | 15.5 | 8−32 | 92.0 | 8.0 | 0.0 | |||
Cefoxitin | 16−64 | 9.8 | 90.2 | 0.0 | 16−32 | 40.0 | 60.0 | 0.0 | 64−> 512 | 0.0 | 1.7 | 98.3 | 16−64 | 12.0 | 88.0 | 0.0 | |||
Ciprofloxacin† | <0.25−>32 | 2.4 | 0.0 | 97.6 | 4−16 | 0.0 | 0.0 | 100.0 | 1−>32 | 8.6 | 17.2 | 74.2 | <0.25−8 | 60.0 | 20.0 | 20.0 | |||
Clarithromycin | <0.12−4 | 97.6 | 2.4 | 0.0 | <0.12 | 100.0 | 0.0 | 0.0 | <0.12−>64 | 98.3 | 0.0 | 2.4 | <0.12−1 | 100.0 | 0.0 | 0.0 | |||
Gatifloxacin‡ | <0.5−>16 | 2.4 | 14.6 | 83.0 | 4−16 | 0.0 | 20.0 | 80.0 | 1−>16 | 31.0 | 44.8 | 24.2 | <0.5−4§ | 80.0 | 20.0 | 0.0 | |||
Imipenem | 1−32 | 14.6 | 53.6 | 31.8 | 8 | 0.0 | 100.0 | 0.0 | <0.5−64 | 10.3 | 34.5 | 55.2 | 1−64 | 16.0 | 44.0 | 40.0 | |||
Linezolid | 4−32 | 43.9 | 36.6 | 19.5 | 8−16 | 20.0 | 60.0 | 20.0 | <0.1−32 | 81.0 | 13.8 | 5.2 | 1−32 | 72.0 | 24.0 | 4.0 | |||
Minocycline | 8−64 | 0.0 | 4.9 | 95.1 | 64 | 0.0 | 0.0 | 100.0 | <0.5−>64 | 15.5 | 3.5 | 81.0 | <0.5−16¶ | 90.9 | 9.1 | 0.0 | |||
Tobramycin | 4−32 | 2.4 | 22.0 | 75.6 | 8−32 | 0.0 | 0.0 | 100.0 | 1−>128 | 98.3 | 0.0 | 1.7 | 4−16# | 62.5 | 29.2 | 8.3 | |||
Trimethoprim/ sulfamethoxazole | 4/76−>16/304 | 0.0 | – | 100.0 | >16/304 | 0.0 | – | 100.0 | <0.5/9.5−>16/304 | 5.2 | – | 94.8 | 1/9−>16/304 | 8.0 | – | 92.0 |
*CV, M. chelonae variant; S, susceptible; I, intermediate; R, resistant; –, not applicable. One CV isolate did not grow on solid media. †Read at 3 days ‡No CLSI breakpoint recommendation has been proposed for gatifloxacin. Manufacturer recommendation of 4 used as the intermediate breakpoint. §10 isolates tested. ¶22 isolates tested. #24 isolates tested.