Table 3. Correlation among diffusion tensor abnormalities, depression, and memory impairment after adjustments for age, sex, education, and history of smoking and alcohol use.

Clinical variable	White Matter Tract	Corresponding cortical area	Correlation (r)	P-value
Fractional anisotropy
Beck Depression Inventory	L Middle Cerebellar Peduncle	L Pons	−0.383	0.005
	L Uncinate Fasciculus	L Frontal lobe, BA13	−0.285	0.039
	L Cingulum	L Cingulate Gyrus, BA 7	−0.315	0.021
Semantic Verbal Fluency	L Cingulum	L Para-hippocampal Gyrus, BA30	0.359	0.008
	L Middle Cerebellar Peduncle	L Pons	0.337	0.014
	L Superior Longitudinal Fasciculus	L Superior Temporal Gyrus, BA 41	0.366	0.007
Digit Span Backward (WASI-R)	L Middle Cerebellar Peduncle	L Pons	0.305	0.025
	L Superior Longitudinal Fasciculus	L Superior Temporal Gyrus, BA 41	0.376	0.006
Digit Span Forward Backward (WASI-R)	L Middle Cerebellar Peduncle	L Pons	−0.282	0.041
Block Design	L Superior Longitudinal Fasciculus	L Superior Temporal Gyrus, BA 41	0.289	0.036
	L Culmen	L Anterior vermis of cerebellum	0.321	0.019
	L Uncinate Fasciculus	L Frontal lobe, BA 13	0.278	0.044
Mean diffusivity
Semantic Verbal Fluency	L Middle Cerebellar Peduncle	L Pons	−0.294	0.033
Radial diffusivity
Beck Depression Inventory	L Middle Cerebellar Peduncle	L Pons	0.343	0.012
Semantic Verbal Fluency	L Cingulum	L Para-hippocampal Gyrus, BA 30	−0.306	0.026
	L Middle Cerebellar Peduncle	L Pons	−0.368	0.007
	L Superior Longitudinal Fasciculus	L Superior Temporal Gyrus, BA 41	−0.356	0.009
Digit Span Backward (WASI-R)	L Superior Longitudinal Fasciculus	L Superior Temporal Gyrus, BA 41	−0.314	0.022
Digit Span Forward-Backward (WASI-R)	L Cingulum	L Para-hippocampal Gyrus, BA 30	0.300	0.029
Block Design	L Middle Cerebellar Peduncle	L Pons	−0.321	0.019

The threshold for statistical significance was set at p<0.05 with correction for multiple comparisons. Boldfaced anatomic regions represent significant correlation between memory tests and DTI indices after further co-varying for BDI score.