Table 1. Significance levels (p values) for gene regions with p≤0.005, for either an association with (i) cervical precancer/cancer, (ii) progression to cervical precancer/cancer, (iii) HPV persistence.
Chromosome | # SNPs | (i) | (ii) | (iii) | |
Gene | CIN3+ (n=415) | CIN3+ (n=415) | HPV persistence (n=356) | ||
vs. RC (n=425)† | vs. HPV persistence (n=356) | vs. RC (n=425) | |||
PRDX3 * | 10q25-q26 | 11 | 0.00015 | 0.0744 | 0.16314 |
RPS19 * | 19q13.2 | 4 | 0.00045 | 0.00585 | 0.45823 |
DDX1 | 2p24 | 13 | 0.0006 | 0.69087 | 0.21284 |
TELO2 | 16p13.3 | 20 | 0.0009 | 0.17849 | 0.65932 |
C1RL | 12p13.31 | 20 | 0.00165 | 0.14029 | 0.00875 |
ILDR1 | 3q13.33 | 11 | 0.00285 | 0.05830 | 0.88461 |
THRAP4 | 6 | 0.00370 | 0.80776 | 0.05615 | |
GDF10 | 10q11.22 | 20 | 0.00400 | 0.13639 | 0.04230 |
GDF2 | 10q11.22 | 19 | 0.00400 | 0.12639 | 0.04080 |
TYMS | 18p11.32 | 20 | 0.0055 | 0.30233 | 0.0015 |
EVPL | 17q25 | 10 | 0.02055 | 0.08985 | 0.00180 |
GC | 4q12-q13 | 19 | 0.0343 | 0.0004 | 0.00965 |
IL2RA | 10p15-p14 | 44 | 0.24394 | 0.00115 | 0.44318 |
PIK3CA | 3q26.3 | 11 | 0.91060 | 0.05145 | 0.00490 |
FDR for both PRDX3 and RPS19=0.19.
RC=random controls.