Table 2. Odds ratios and 95% confidence intervals for top-ranked SNPs (p≤0.0001) with either an association with (i) cervical precancer/cancer, (ii) progression to cervical precancer/cancer, or (iii) HPV persistence: (all models adjusted for age).
| Gene | rs # | Random control | HPV persistence | CIN3/cancer | CIN3/cancer | CIN3/cancer vs | HPV persistence |
| vs RC | HPV persistence | vs RC | |||||
| N (%) | N (%) | N (%) | OR (95% CI) | OR (95% CI) | OR (95% CI) | ||
| PRDX3 | RS7082598 | ||||||
| CC | 288 (68) | 266 (75) | 346 (83) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| CT | 127 (30) | 87 (24) | 64 (15) | 0.41 (0.29–0.58) | 0.55 (0.38–0.80) | 0.74 (0.53–1.01) | |
| TT | 10 (2) | 3 (1) | 5 (1) | 0.45 (0.15–1.35) | 1.29 (0.29–5.65) | 0.33 (0.09–1.20) | |
| p-trend<0.00001 | p-trend=0.008 | p-trend=0.02 | |||||
| CT/TT | 137 (32) | 90 (25) | 69 (17) | 0.41 (0.30–0.58) | 0.58 (0.40–0.83) | 0.71 (0.52–0.97) | |
| RPS19 | RS2305809 | ||||||
| CC | 100 (24) | 102 (29) | 141 (34) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| CT | 228 (54) | 172 (48) | 213 (51) | 0.66 (0.48–0.91) | 0.83 (0.59–1.15) | 0.74 (0.53–1.05) | |
| TT | 97 (23) | 82 (23) | 60 (14) | 0.43 (0.28–0.66) | 0.51 (0.33–0.78) | 0.83 (0.56–1.25) | |
| p-trend=0.00007 | p-trend=0.003 | p-trend=0.34 | |||||
| CT/TT | 325 (76) | 254 (71) | 273 (66) | 0.59 (0.43–0.80) | 0.72 (0.53–0.99) | 0.77 (0.56–1.06) | |
| Il2RA | RS2476491 | ||||||
| AA | 262 (62) | 196 (55) | 289 (70) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| AT | 147 (35) | 135 (38) | 114 (27) | 0.69 (0.51–0.93) | 0.56 (0.41–0.77) | 1.22 (0.91–1.65) | |
| TT | 15 (4) | 25 (7) | 12 (3) | 0.68 (0.31–1.5) | 0.34 (0.16–0.70) | 2.24 (1.15–4.37) | |
| p-trend=0.02 | p-trend=0.00002 | p-trend=0.02 | |||||
| AT/TT | 162 (38) | 160 (45) | 126 (30) | 0.69 (0.51–0.92) | 0.53 (0.39–0.71) | 1.32 (0.99–1.76) | |
| TELO2 | RS4786772 | ||||||
| AA | 185 (44) | 151 (42) | 134 (32) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| AG | 197 (46) | 147 (41) | 211 (51) | 1.54 (1.14–2.09) | 1.65 (1.19–2.27) | 0.92 (0.68–1.24) | |
| GG | 42 (10) | 58 (16) | 69 (17) | 2.51 (1.59–3.94) | 1.40 (0.91–2.15) | 1.68 (1.06–2.65) | |
| p-trend=0.00002 | p-trend=0.03 | p-trend=0.13 | |||||
| AG/GG | 239 (56) | 205 (58) | 280 (68) | 1.71 (1.28–2.28) | 1.57 (1.16–2.13) | 1.05 (0.79–1.39) | |
| C1RL | RS12227050 | ||||||
| GG | 402 (95) | 310 (87) | 357 (86) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| AG | 22 (5) | 45 (13) | 57 (14) | 2.91 (1.73–4.89) | 1.06 (0.69–1.62) | 2.73 (1.60–4.65) | |
| AA | 1 (0.2) | 1 (0.3) | 1 (0.2) | 1.37 (0.08–22.18) | 0.77 (0.05–12.91) | 1.36 (0.08–21.92) | |
| p-trend=0.0001 | p-trend=0.85 | p-trend=0.0004 | |||||
| AG/AA | 23 (5) | 46 (13) | 58 (14) | 2.85 (1.71–4.74) | 1.05 (0.69–1.61) | 2.67 (1.58–4.51) | |
| TYMS | RS2342700 | ||||||
| CC | 227 (53) | 145 (41) | 169 (41) | 1.0 (ref) | 1.0 (ref) | 1.0 (ref) | |
| CG | 169 (40) | 164 (46) | 199 (48) | 1.56 (1.17–2.09) | 1.06 (0.78–1.44) | 1.53 (1.13–2.06) | |
| GG | 29 (7) | 47 (13) | 46 (11) | 2.18 (1.30–3.64) | 0.87 (0.54–1.40) | 2.57 (1.54–4.27) | |
| p-trend=0.0002 | p-trend=0.78 | p-trend=0.00005 | |||||
| CG/GG | 198 (47) | 211 (59) | 245 (59) | 1.65 (1.25–2.18) | 1.02 (0.76–1.37) | 1.68 (1.26–2.23) |