Figure 1.
Variants in the Region of IRF8 Tested for Association with SLE
The association between IRF8 and SLE in European (A), African American (B), and Asian (C) ancestral populations is given with observed (blue diamonds) and imputed (red circles) variants. The dotted line represents the Bonferroni-corrected threshold (p = 1.09 × 10−4) for the fine-mapping study. The solid black line represents the recombination rate. The variants labeled with blue text represent the most significant observed SNPs, whereas the variants labeled in red represent the most significant SNPs after imputation. In the Asians, rs11117427 was both the most significant observed and imputed variant.
(D) Shown is an expanded view of the most statistically significant region in Europeans (circles), African Americans (triangles), and Asians (squares) for selected variants tagged by rs8046526 (purple), rs450443 (turquoise), rs4843869 (yellow-orange), and rs11117427 (green). The following abbreviation is used: Recomb., recombination.