Table 3.

Replicated Loci that Demonstrate Suggestive Evidence of SLE Risk^a

SNP	Locus	Allelesb	European					Test of Heterogeneity
			pGWA scanc	ORGWA scan (95% Cl)	pREP	ORREP (95% Cl)	pMETA-Euro	pQd	I2
rs7542235	CFHR1	A/G	3.94 × 10−3	1.30 (1.11–1.54)	1.10 × 10−3	1.15 (1.06–1.25)	1.85 × 10−5	0.180	44.4%
rs485499	LOC730109/IL12A	A/G	2.14 × 10−3	0.75 (0.65–0.87)	1.47 × 10−4	0.87 (0.81–0.94)	1.31 × 10−6	0.076	68.2%
rs669003	LOC730109/IL12A	A/G	2.16 × 10−3	0.75 (0.65–0.87)	1.15 × 10−4	0.87 (0.81–0.93)	1.02 × 10−6	0.081	67.2%
rs7631930	LPP	A/G	3.60 × 10−3	1.25 (1.06–1.49)	1.66 × 10−3	1.15 (1.05–1.25)	2.71 × 10−5	0.375	0.00%
rs9310002	CADM2	G/A	2.09 × 10−3	2.06 (1.38–3.07)	6.12 × 10−3	1.39 (1.10–1.76)	8.30 × 10−5	0.099	63.3%
rs1075059	LOC63920	A/C	7.30 × 10−4	0.82 (0.71–0.95)	7.26 × 10−3	0.91 (0.85–0.97)	5.27 × 10−5	0.221	33.2%
rs1895321	SLU7	A/C	4.21 × 10−3	1.22 (1.06–1.41)	3.11 × 10−3	1.11 (1.04–1.19)	6.09 × 10−5	0.260	21.2%
rs7039790	ADAMTSL1	C/A	5.36 × 10−3	1.62 (1.24–2.12)	1.14 × 10−3	1.27 (1.10–1.47)	2.38 × 10−5	0.124	57.7%
rs2940712	C10orf64	G/A	4.72 × 10−3	0.79 (0.67–0.91)	8.73 × 10−4	0.88 (0.82–0.95)	1.62 × 10−5	0.178	45.0%
rs10790605	OR8D4	G/A	2.02 × 10−3	0.80 (0.67–0.95)	4.35 × 10−3	0.88 (0.81–0.96)	5.39 × 10−5	0.321	0.00%
rs7960162	FAM19A2	A/G	4.95 × 10−3	0.76 (0.61–0.94)	4.31 × 10−3	0.87 (0.79–0.96)	9.79 × 10−5	0.253	23.6%
rs749373	STXBP6	A/G	5.44 × 10−3	1.34 (1.11–1.62)	2.32 × 10−3	1.16 (1.05–1.27)	5.26 × 10−5	0.171	46.7%

The following abbreviation is used: GWA, genome-wide association; OR, odds ratio; CI, confidence interval; and REP, replication.

^aTable S7 contains results for all populations evaluated within this study.

^bMajor/minor alleles.

^cGWA scan previously reported in Graham et al.¹

^dCochran's Q test statistic.