Table 3.

Association Results of Combined-Phenotype Meta-Analysis Considering Same-Direction Effects of Alleles from COMBINED Approach

Chr	SNP	A1	Locus	CD+PS Discovery GWAS (4,671/10,460)		PS GWAS (2,529/4,955)		CD GWAS (2,142/5,505)		PS Replication (3,187/4,759)		CD Replication (4,073/2,478)
				p	OR	p	OR	p	OR	p	OR	p	OR
10	rs1250544a	G	ZMIZ1	1.12 × 10−05	1.13	3.85 × 10−05	1.18	3.31 × 10−02	1.09	1.94 × 10−04	1.14	5.28 × 10−07	1.22
10	rs1250560b	A	ZMIZ1	3.13 × 10−06	0.87	4.31 × 10−06	0.82	4.87 × 10−02	0.92	1.06 × 10−03	0.87	8.06 × 10−10	0.79
10	rs1250559b	A	ZMIZ1	1.53 × 10−07	0.87	4.58 × 10−06	0.82	3.46 × 10−02	0.91	1.16 × 10−03	0.87	4.10 × 10−10	0.79
16	rs4780355a	T	SOCS1	9.36 × 10−07	1.16	1.72 × 10−04	1.18	1.47 × 10−03	1.15	7.53 × 10−04	1.14	7.40 × 10−06	1.19

The following abbreviations are used: Chr: chromosome of marker; SNP: rs ID; A1: minor allele; Locus: one candidate gene in the region; p/OR: p value and corresponding odds ratio with respect to minor allele for the combined-phenotype GWAS meta-analysis of CD and PS (panels A and B), GWAS meta-analysis of PS (panel A), GWAS meta-analysis of CD (panel B), PS replication analysis (as part of panel D), CD replication analysis (part of panel D, panel E). For each panel, numbers of cases/controls are displayed in parentheses. None of the SNPs showed an exact Hardy-Weinberg p value < 0.01 in the PS and CD replication panels (panels D and E).

^aSNPs were identified via genotype imputation based on the HapMap3 reference and P/OR are given according to that analysis.

^bSNPs were identified via genotype imputation based on the 1000 Genomes reference and P/OR are given according to that analysis.