Table 4.
Association Results of Combined-Phenotype Meta-Analysis Considering Same-Direction Effects of Alleles from COMBINED Approach
| Chr | SNP | A1 | Locus |
PS GWAS and Repl (5,716/9,714) |
CD GWAS and Repl (6,215/7,983) |
CD+PS GWAS and Repl (11,931/17,697) |
Status Now | |||
|---|---|---|---|---|---|---|---|---|---|---|
| p | OR | p | OR | p | OR | |||||
| 10 | rs1250544a | G | ZMIZ1 | 3.53 × 10−08 | 1.16 | 2.56 × 10−07 | 1.16 | 7.32 × 10−14 | 1.16 | PS, CD-PS, CD |
| 10 | rs1250560b | A | ZMIZ1 | 3.03 × 10−07 | 0.84 | 4.10 × 10−09 | 0.84 | 7.34 × 10−16 | 0.85 | CD-PS, CD |
| 10 | rs1250559b | A | ZMIZ1 | 3.63 × 10−07 | 0.84 | 1.24 × 10−09 | 0.84 | 2.78 × 10−16 | 0.85 | CD-PS, CD |
| 16 | rs4780355a | T | SOCS1 | 5.30 × 10−07 | 1.15 | 4.99 × 10−08 | 1.17 | 1.37 × 10−13 | 1.16 | CD-PS, CD |
For abbreviations used, see Table 3. Combined analysis of PS GWAS meta-analysis (panel A) and PS replication (part of panel D), combined analysis of CD GWAS meta-analysis (panel B) and CD replication (part of panel D, panel E), combined analysis of CD+PS GWAS meta-analysis (panels A and B) and CD+PS replication (panels D and E).
a
SNPs were identified via genotype imputation based on the HapMap3 reference and p/OR are given according to that analysis.
b
SNPs were identified via genotype imputation based on the 1000 Genomes reference and p/OR are given according to that analysis.