Table-1.
Intralipid improves heart functional recovery against reperfusion injury through PI3K/Akt pathways
| LVSP mmHg |
LVEDP mmHg |
LVDP mmHg |
HR Beats/min |
|
|---|---|---|---|---|
| Baseline | ||||
| CTRL | 99±10 | 4±2 | 95±11 | 188±44 |
| ILP | 96±6 | 2±1 | 94±6 | 161±32 |
| ILP+LY | 88±4 | 3±1 | 85±5 | 197±12 |
| LY | 77±2 | 4±2 | 73±2 | 241±17 |
| Reperfusion | ||||
| 10 min | ||||
| CTRL | 15±2 | 4±1 | 11±3 | 135±28 |
| ILP | 80±16** | 3±1 | 77±5** | 139±32 |
| ILP+LY | 21±4 | 9±3 | 12±2 | 207±26 |
| LY | 33±6 | 12±6 | 21±3 | 108±7 |
| 20 min | ||||
| CTRL | 16±3 | 4±2 | 12±3 | 209±28 |
| ILP | 77±12** | 8±3 | 69±6** | 169±25 |
| ILP+LY | 21±5 | 7±2 | 14±3 | 222±22 |
| LY | 21±5 | 4±2 | 17±3 | 133±12 |
| 30 min | ||||
| CTRL | 16±2 | 5±1 | 11±2 | 223±39 |
| ILP | 73±13** | 6±2 | 67±7** | 177±18 |
| ILP+LY | 25±7 | 8±2 | 17±2 | 221±28 |
| LY | 23±3 | 2±1 | 21±4 | 194±13 |
| 40 min | ||||
| CTRL | 19±4 | 6±2 | 13±3 | 219±36 |
| ILP | 80±16** | 5±2 | 75±8** | 157±14 |
| ILP+LY | 22±4 | 4±1 | 18±3 | 221±23 |
| LY | 27±6 | 6±4 | 21±3 | 189±23 |
Cardiac functional recovery parameters of left ventricular systolic pressure (LVSP); left ventricular end-diastolic pressure (LVEDP); left ventricular developed pressure (LVDP) and heart rate (HR) before ischemia (baseline) and at different times of reperfusion in control group (CTRL), 1% Intralipid (ILP), 1% Intralipid+LY294002 (ILP+LY) and LY294002 alone (LY).
Values are Mean ± SEM;
**
P < 0.01 vs CTRL (n = 6).