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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Dev Biol. 2012 Feb 25;365(1):219–228. doi: 10.1016/j.ydbio.2012.02.027

Figure 2. lgl mutant and aPKCcaax overexpressing INPs revert back to type II neuroblasts.

Figure 2

(A–B) Wild-type and lgl334/3644 mutant brains expressed erm-lacZ specifically in INPs, but not in neuroblasts. (C–D) While an INP-derived clone in a wild-type brain only contained neurons, an INP-derived clone in an lgl334/3644 mutant brain contained multiple supernumerary type II neuroblasts. (n = 31 and 21 brains, respectively) (E–F) Overexpression of aPKCcaax driven by Erm-GAL4 leads to supernumerary type II neuroblasts in comparison to a wild-type brain. (n = 8 and 9 brains, respectively) Brains were stained with the indicated markers. Clones marked by β-galactosidase are circled by the dotted line. Arrows indicate the neuroblasts (white, Type I; yellow, Type II) and yellow arrowheads indicate the INPs. All scale bars are 10 μm.