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. Author manuscript; available in PMC: 2013 Apr 6.
Published in final edited form as: Biochem Biophys Res Commun. 2012 Mar 7;420(2):325–330. doi: 10.1016/j.bbrc.2012.02.158

Fig. 4. Effects of SAHA on RhoA activity, apoptosis and cell cycle progression.

Fig. 4

A: Effect of SAHA and DLC1 on RhoA activity. DLC1 or vector only transduced 22Rv1 cells were treated with SAHA or DMSO. Twenty-four hrs after treatment, cells were lysed and equal amounts of cell lysates were subjected to G-Lisa RhoA assay. B: Effects of SAHA and DLC1 on apoptosis and cell cycle. DLC1 or vector only transduced 22Rv1 cells were treated with SAHA or DMSO. The percentage of cells in the sub-G1 phase (arrow) was significantly increased upon DLC1 or/and SAHA treatment for 24 hrs. Vector and DMSO (a), DLC1 and DMSO (b), Vector and SAHA (c), DLC1 plus SAHA (d).