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. Author manuscript; available in PMC: 2013 Apr 25.
Published in final edited form as: Neurosci Lett. 2012 Mar 16;515(1):61–65. doi: 10.1016/j.neulet.2012.03.019

Figure 1.

Figure 1

In vivo local perfusion of the L5 DRG with S1P increases mechanical sensitivity of the ipsilateral hindpaw. Perfusion with 100 μM S1P or vehicle (ACSF) at 1μL/hour occurred during the first 7 days (shaded area). The baseline plotted on day 0 is the average of 3 measurements made on preceding days. Data were normalized to the average baseline value for all animals, which did not differ between the two groups. *, significant difference between S1P and ACSF groups (2 way ANOVA with Bonferroni posttest). In all figures the significance level is indicated by the number of symbols (see Methods). N = 4 animals per group.