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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Pharmacol Toxicol Methods. 2012 Feb 26;65(2):64–74. doi: 10.1016/j.vascn.2012.02.002

Fig. 4.

Fig. 4

Plot (log-log) of the IC50 values for Pgp transport inhibition obtained with Fl-t-pgp and Kd values for Pgp binding for 33 test compounds. IC50 values for transport inhibition were determined using the Fl-t-pgp assay, and Kd values were determined by fluorescence quenching of purified Pgp in 2 mM CHAPS.