Figure 11. 2ME2 treatment down-regulates radio-ligand binding in rat aortic smooth muscle cells.
Cells were exposed to 2ME2 (1 μM) for 24 h and [3H]AngII binding measured in the presence or absence of losartan (an AT1R specific antagonist) PD123319 (an AT2R specific antagonist), or PD98059 (a specific MEK inhibitor). (n=9). Data are expressed as mean ± SEM ***p<0.0001 versus untreated control.