Table 3.

Doppler Measurements

Parameters	WT-SHAM (n=7)	KO-SHAM (n=7)	p value
E (cm/s)	59.87 ± 4.06	65.54 ± 3.58	NS
A (cm/s)	35.94 ± 2.41	29.50 ± 1.02#	#<0.05
E/A	1.67 ± 0.03	2.24 ± 0.15#	#<0.01
DCT (msec)	34.17 ± 1.27	30.02 ± 1.39#	#<0.05
ET (msec)	52.43 ± 2.48	52.41 ± 2.03	NS
IVRT (msec)	30.50 ± 4.64	28.22 ± 3.60	NS
IVCT (msec)	31.17 ± 3.68	30.63 ± 2.22	NS
HR	323.65±19.71	333.48±14.79	NS

Values are mean ±SE; E, peak velocity of the early ventricular filling; A, peak velocity of the late ventricular filling; DCT, E wave deceleration time; IVRT, isovolumic relaxation time; IVCT, isovolumic contraction time; HR, heart rate

^#comparison between genotypes. NS, not significant