Skip to main content
. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Microbes Infect. 2011 Dec 17;14(5):392–400. doi: 10.1016/j.micinf.2011.12.005

Figure 1.

Figure 1

Schematic overview of the domains of the intracellular sensor Nlrp1 from human, rat, and mouse. The genomes of mice contain three Nlrp1 paralogs on chromosome 11 (Nlrp1a, Nlrp1b, and Nlrp1c) and different mouse strains express two or three of these proteins, as well as different splice variants. Human Nlrp1 contains an ASC-interacting pyrin domain that is absent in rodent Nlrp1s. Rodent Nlrp1s have a unique N-terminal region (NR100, for “N-terminal domain of rodent Nlrp1of about 100 amino acids”) with no sequence homology to human Nlrp1 and limited homology between the rodent species and paralogs, as indicated by shading in the figure. Other domains shown are: NBD/NACHT, nucleotide binding ATPase domain; LRR, leucine-rich repeats; FIIND, function-to-find domain; CARD, caspase-1 recruitment domain. Please note that the relative size of domains is not to scale, and the number of LRR domain repeats differs based on species and paralog and can also vary depending on the algorithms used to assign them.