Table 5.
The top 30 most significantly associated 11-probe regions.
| Probe ID | Gene | Placement | Island status | Average methylation |
p-Value* | Step up p-value | |
|---|---|---|---|---|---|---|---|
| Abs | Heavy | ||||||
| cg24338351 | BLCAP | 5’UTR | Island | 0.69 | 0.76 | 1.86E−10 | 4.75E−05 |
| cg24675557 | BLCAP | 5’UTR | Island | 0.68 | 0.75 | 2.36E−10 | 4.75E−05 |
| cg01466133 | BLCAP | 5’UTR | Island | 0.71 | 0.77 | 3.86E−10 | 4.75E−05 |
| cg20479660 | BLCAP | 5’UTR | Island | 0.68 | 0.74 | 3.91E−10 | 4.75E−05 |
| cg07557337 | RAB1B | TSS200 | Island | 0.07 | 0.07 | 1.29E−08 | 0.0011 |
| cg26522319 | C1orf103 | 1st exon | Island | 0.05 | 0.06 | 1.53E−08 | 0.0011 |
| cg02898883 | RAB1B | TSS1500 | Island | 0.07 | 0.07 | 1.69E−08 | 0.0011 |
| cg03436478 | SGCE, PEG10 | S_shore | 0.51 | 0.52 | 2.28E−08 | 0.0013 | |
| cg09337653 | SIN3A, SIN3A | Island | 0.08 | 0.08 | 3.29E−08 | 0.0016 | |
| cg27535677 | N_shore | 0.70 | 0.75 | 3.30E−08 | 0.0016 | ||
| cg20041873 | SGCE, PEG10 | S_shore | 0.51 | 0.53 | 3.86E−08 | 0.0017 | |
| cg07156273 | BLCAP | 5’UTR | Island | 0.71 | 0.77 | 4.87E−08 | 0.0019 |
| cg24141738 | ERMAP, CCDC23 | Island | 0.04 | 0.05 | 5.25E−08 | 0.0019 | |
| cg15473473 | BLCAP | 5’UTR | Island | 0.71 | 0.77 | 6.14E−08 | 0.0020 |
| cg04303139 | SGCE, PEG10 | S_shore | 0.51 | 0.52 | 6.34E−08 | 0.0020 | |
| cg01758634 | SIN3A | TSS1500 | Island | 0.07 | 0.08 | 6.87E−08 | 0.0020 |
| cg05509218 | SGCE, PEG10 | S_shore | 0.49 | 0.51 | 8.89E−08 | 0.0025 | |
| cg22421148 | BLCAP | 5’UTR | Island | 0.66 | 0.73 | 9.73E−08 | 0.0026 |
| cg03759229 | N_shore | 0.68 | 0.73 | 1.14E−07 | 0.0029 | ||
| cg22893248 | ACTR3C | 1st exon | Island | 0.07 | 0.10 | 1.25E−07 | 0.0030 |
| cg20631204 | ZNF562 | TSS200 | Island | 0.11 | 0.13 | 1.34E−07 | 0.0031 |
| cg02639123 | ACTR3C, LRRC61 | S_shore | 0.21 | 0.23 | 1.47E−07 | 0.0031 | |
| cg01959416 | ACTR3C, LRRC61 | S_shore | 0.07 | 0.10 | 1.47E−07 | 0.0031 | |
| cg12862537 | BLCAP | 5’UTR | Island | 0.76 | 0.82 | 1.63E−07 | 0.0031 |
| cg22497095 | N_shore | 0.70 | 0.75 | 1.64E−07 | 0.0031 | ||
| cg21516287 | ACTR3C, LRRC61 | S_shore | 0.14 | 0.16 | 1.68E−07 | 0.0031 | |
| cg26544607 | ARRDC3 | S_shelf | 0.07 | 0.07 | 1.88E−07 | 0.0032 | |
| cg04558861 | LIN37 | TSS200 | N_shore | 0.12 | 0.13 | 1.89E−07 | 0.0032 |
| cg22510412 | BLCAP | 5’UTR | Island | 0.64 | 0.70 | 2.00E−07 | 0.0032 |
| cg19998456 | GGA1 | TSS200 | Island | 0.05 | 0.06 | 2.03E−07 | 0.0032 |
*Nominal p-value before Benjamini–Hochberg step up correction. Abs, abstinent; S, south; N, north. All methylation values are average beta values. Probe listed is the probe in the center of the linearly arranged group of 11-probes.