Table 2.
Cytokine/Chemokine Profiles in the F344 and HIV-1Tg Rat Brain
| Cytokines and Chemokines in the Brain with LPS Treatment | |||||||
|---|---|---|---|---|---|---|---|
| Protein (pg/ml, ± SD) | |||||||
| F344 | IL-1β | KC/GRO | IL-4 | IL-5 | TNF-α | IFN-γ | IL-13 |
| Interleukin 1 beta | Interleukin 4 | Interleukin 5 | Tumor necrosis factor - alpha | Interferon gamma | Interleukin 13 | ||
| SS+S | 42.2(± 8.8) | 74.4(± 23.3) | ND | 56.5(±) | ND | 15.3(± 7.5) | 4.4(± 1.8) |
| SS+L | 178.4(± 162.1) | 1325.3(± 1431.3) | 13.5() | 102.8(± 61.1) | 30.9 | 20.5(± 11.9) | 4.8(± 3.1) |
| LL+S | 59.1(± 26.3) | 112.6(± 35.6) | 3.4 | 74.7 | ND | 14.7(± 7.0) | 6.9(± 1.4) |
| LL+L | 207.0(± 133.0) | 1036.2(± 685.6) | 2.9(± 1.3) | 141.9(± 98.3) | ND | 21.9(± 6.5) | 5.3(± 2.3) |
| HIV - 1Tg | IL-1β | KC/GRO | IL-4 | IL-5 | TNF-α | IFN-γ | IL-13 |
| Interleukin 1 beta | Interleukin 4 | Interleukin 5 | Tumor necrosis factor - alpha | Interferon gamma | Interleukin 13 | ||
| SS+S | 37.3(± 17.1) | 125.3(± 87.8) | ND | ND | ND | 11.7(± 5.2) | 5.1(± 0.4) |
| SS+L | 361.7(± 104.6)* | 2991.3(± 491.5)** | 9.2(± 3.1) | 164.2(± 35.3) | 109.5 | 47.1(± 14.5)* | 9.3(± 4.2) |
| LL+S | 56.5(± 15.1) | 128.1(± 61.6) | ND | ND | ND | 8.9(± 5.9) | 4.6(± 1.4) |
| LL+L | 208.6(± 167.4) | 1312.9(± 1039.2)^ | 8.1(± 1.6) | 181.2(± 50.0) | 27.3 | 24.3(± 14.5)^ | 7.3(± 3.7) |
* P < 0.05, ** P < 0.01, *** P < 0.001 greater SS+S control; ^ P < 0.05, ^^ P < 0.01, ^^^ P < 0.001 less than SS+L; statistically significant changes are bolded