Table 3.
Cytokine/Chemokine Profiles in the F344 and HIV-1Tg Rat Spleen
| Cytokines and Chemokines in the Spleen with LPS Treatment | |||||||
|---|---|---|---|---|---|---|---|
| Protein (pg/ml, ± SD) | |||||||
| F344 | IL-1β | KC/GRO | IL-4 | IL-5 | TNF-α | IFN-γ | IL-13 |
| Interleukin 1 beta | Interleukin 4 | Interleukin 5 | Tumor necrosis factor - alpha | Interferon gamma | Interleukin 13 | ||
| SS+S | 1802.9(± 635.7) | 264.7(± 122.7) | 6.9(± 3.3) | 119.5(± 20.0) | ND | 34.5(± 13.6) | 3.7(± 2.3) |
| SS+L | 19030.7(± 11365.4)* | 20065.6(± 11858.1) | 50.7(± 16.0)** | 344.4(± 83.9)** | 2943.6(± 2752.3) | 203.3(± 71.5)** | 22.1(± 6.0)** |
| LL+S | 3325.3(± 440.6) | 506.6(± 205.0) | 6.8(± 5.7) | 120.0(± 28.8) | ND | 32.5(± 28.1) | 3.8(± 3.0) |
| LL+L | 7898(± 1996.9)^ | 11818.7(± 9648.2) | 21.6(± 10.2)^^ | 246.6(± 79.4) | 228.7(± 19.6) | 105.3(± 45.0)*^ | 14.2(± 6.1) |
| HIV - 1Tg | IL-1β | KC/GRO | IL-4 | IL-5 | TNF-α | IFN-γ | IL-13 |
| Interleukin 1 beta | Interleukin 4 | Interleukin 5 | Tumor necrosis factor - α | Interferon gamma | Interleukin 13 | ||
| SS+S | 1274.5(± 122.3) | 361.1(± 187.7) | 3.8(± 1.4) | 107.7(± 33.0) | ND | 10.8(± 4.8) | 0.8(± 0.7) |
| SS+L | 19951.8(± 4023.8)** | 25812.5(± 3014.5)** | 41.8(± 5.7)** | 395.4(± 93.3)** | 2755.4(± 1596.0) | 296.9(± 83.4)** | 32.0(± 4.9)* |
| LL+S | 5087.1(± 1675.4) | 961.8(± 89.1) | 7.3(± 2.0) | 178.4(± 57.2) | ND | 19.8(± 2.6) | 6.6(± 6.4) |
| LL+L | 11443.1(± 7400)*^ | 12754.4(± 11613.3)^ | 27.3(± 12.6)*^ | 239.4(± 77.1)^ | 356.7(± 149.4) | 151.5(± 77.6)*^ | 19.8(± 11.4) |
* P < 0.05, ** P < 0.01, *** P < 0.001 greater than SS+S control; ^ P < 0.05, ^^ P < 0.01, ^^^ P < 0.001 less than SS+L; statistically significant changes are bolded