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. Author manuscript; available in PMC: 2013 Apr 4.
Published in final edited form as: Structure. 2012 Apr 3;20(4):582–592. doi: 10.1016/j.str.2012.02.017

Figure 2. Selection of a suitable Fab to enable single particle cryoEM studies of HIV-1 IN.

Figure 2

(A–D): EM micrographs of HIV-1 IN in complex with four different Fabs. It is obvious that IN-Fab2 and IN-Fab5 are more homogeneous than the other two IN-Fab complexes. Inserted in (B) and (D) are representative 2D class averages of IN-Fab2 and IN-Fab5 complexes. In all 2D class averages, there are two Fabs bound to one IN dimer.