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. Author manuscript; available in PMC: 2012 Oct 5.
Published in final edited form as: Nature. 2012 Apr 4;484(7392):55–61. doi: 10.1038/nature10944

Figure 6. Contributions of coding and regulatory changes to parallel marine-freshwater stickleback adaptation.

Figure 6

a. A genome-wide set of marine-freshwater loci recovered by both SOM/HMM and CSS analyses includes regions with consistent amino acid substitutions between marine and freshwater ecotypes (yellow sector); regions with no predicted coding sequence (green sector); and regions with both coding and non-coding sequences, but no consistent marine-freshwater amino acid substitutions (grey). b. Genome-wide expression analysis shows that marine-freshwater regions identified by SOM/HMM or CSS analyses are enriched for genes showing significant expression differences in 6 out of 7 tissues between marine LITC and freshwater FTC fish (observed: grey bars; expected: white bars; * P<0.01, **P<0.001, ***P<0.0001, ****P≪0.00001), consistent with a role for regulatory changes in marine-freshwater evolution.