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. Author manuscript; available in PMC: 2012 Apr 10.
Published in final edited form as: HIV Clin Trials. 2011 Sep-Oct;12(5):277–285. doi: 10.1310/hct1205-277

Table 1.

Well-established genetic associations for antiretroviral drugs

Drug Genotype Phenotype References
Abacavir HLA-B*5701 Hypersensitivity reaction 3–6
Atazanavir, indinavir UGT1A1*28 Hyperbilirubinemia 25–27
Efavirenz CYP2B6 516G→T, 983T→C, others Increased plasma concentration 8–13
Lopinavir SLCO1B1 521T→C Increased plasma concentration 18, 19, 28
Nelfinavir CYP2C19 681G→A Increased plasma concentration 10, 29
Nevirapine CYP2B6 516G→T Increased plasma concentration 9, 30–32
Nevirapine HLA-B*3505, -Cw*04, -DR*0101 Hypersensitivity reaction 14–17
Protease inhibitors APOC, others Dyslipidemia 21, 33, 34