Table 4.
50 mmHg (n = 8) |
100 mmHg (n = 8) |
150 mmHg (n = 8) |
|||||||
---|---|---|---|---|---|---|---|---|---|
0 weeks | 2 weeks | 4 weeks | 0 weeks | 2 weeks | 4 weeks | 0 weeks | 2 weeks | 4 weeks | |
Baseline SBP (mmHg) | 120 ± 6.4 | 118 ± 5.2 | 116 ± 4.8 | 121 ± 3.4 | 117 ± 1.8 | 120 ± 1.8 | 119 ± 4.5 | 120 ± 2.8 | 118 ± 3.3 |
Baseline DBP (mmHg) | 68 ± 4.0 | 61 ± 2.3* | 58 ± 2.1* | 67 ± 4.4 | 67 ± 2.8 | 68 ± 3.3 | 66 ± 2.9 | 66 ± 3.6 | 63 ± 2.7 |
Baseline MAP (mmHg) | 85 ± 3.8 | 80 ± 2.4* | 78 ± 1.3* | 85 ± 3.1 | 83 ± 2.3 | 85 ± 2.4 | 83 ± 2.9 | 84 ± 3.1 | 81 ± 2.7 |
Baseline HR (bpm) | 63 ± 5.5 | 57 ± 4.4 | 56 ± 3.7 | 55 ± 3.7 | 56 ± 3.0 | 54 ± 2.6 | 60 ± 4.0 | 57 ± 2.6 | 60 ± 3.5 |
RH SBP (mmHg) | 122 ± 5.2 | 116 ± 5.5 | 115 ± 4.3 | 122 ± 4.2 | 117 ± 2.6 | 120 ± 2.1 | 118 ± 4.0 | 121 ± 2.7 | 117 ± 2.4 |
RH DBP (mmHg) | 73 ± 2.7 | 59 ± 3.3* | 62 ± 1.6* | 68 ± 5.2 | 72 ± 3.3 | 73 ± 3.6 | 65 ± 4.0 | 65 ± 2.9 | 66 ± 3.3 |
RH MAP (mmHg) | 89 ± 2.9 | 78 ± 3.2* | 79 ± 1.9* | 86 ± 4.3 | 87 ± 2.7 | 88 ± 2.9 | 82 ± 2.1 | 84 ± 2.6 | 83 ± 3.0 |
RH HR (bpm) | 60 ± 5.0 | 54 ± 3.5* | 55 ± 4.3* | 55 ± 3.0 | 55 ± 3.5 | 54 ± 3.0 | 61 ± 3.0 | 57 ± 2.6 | 56 ± 2.4 |
Baseline FBF (ml(100 ml)−1 min−1) | 2.5 ± 0.4 | 1.7 ± 0.3 | 2.4 ± 0.6 | 2.0 ± 0.2 | 2.6 ± 0.6 | 2.1 ± 0.2 | 2.4 ± 0.7 | 3.0 ± 0.8 | 2.4 ± 0.7 |
Baseline FVC (ml(100 ml)−1 min−1 mmHg−1) |
0.3 ± 0.08 | 0.2 ± 0.04 | 0.3 ± 0.06 | 0.2 ± 0.03 | 0.3 ± 0.07 | 0.3 ± 0.03 | 0.3 ± 0.07 | 0.3 ± 0.1 | 0.3 ± 0.1 |
PBF (ml(100 ml)−1 min−1) | 23 ± 1.6 | 19 ± 1.8 | 19 ± 2.6 | 24 ± 2.5 | 24 ± 2.8 | 21 ± 1.4 | 21 ± 2.2 | 24 ± 1.8 | 25 ± 2.8 |
PVC (ml(100 ml)−1 min−1 mmHg−1) | 0.2 ± 0.02 | 0.2 ± 0.02 | 0.2 ± 0.03 | 0.2 ± 0.02 | 0.2 ± 0.03 | 0.2 ± 0.01 | 0.2 ± 0.02 | 0.2 ± 0.02 | 0.3 ± 0.03 |
AUCSR | 1510 ± 122 | 1303 ± 128 | 1312 ± 162 | 1745 ± 244 | 1791 ± 234 | 1448 ± 109 | 1412 ± 202 | 1699 ± 118 | 1690 ± 129 |
AUCRH | 293 ± 40 | 226 ± 30 | 231 ± 26 | 342 ± 50 | 346 ± 44 | 262 ± 15 | 264 ± 39 | 303 ± 42 | 299 ± 27 |
FMD (%) | 8.7 ± 1.2 | 7.5 ± 1.4 | 8.3 ± 1.4 | 7.7 ± 0.9 | 10.7 ± 1 | 10.4 ± 2 | 12 ± 1.9 | 11.5 ± 1 | 11.7 ± 1.6 |
FMD/AUCSR | 0.007 ± 0.0008 | 0.008 ± 0.001 | 0.01 ± 0.001 | 0.005 ± 0.0005 | 0.007 ± 0.0005 | 0.008 ± 0.001 | 0.009 ± 0.001 | 0.009 ± 0.0008 | 0.008 ± 0.0008 |
Values are as mean ± SE
SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, HR heart rate, RH reactive hyperemia, PBF peak blood flow, PVC peak vascular conductance, AUCSR shear rate area under the curve, AUCRH blood flow area under the curve of the reactive hyperemic response
Significant difference from 0 weeks (baseline) at P < 0.01