Table 2.
The most significantly altered genes within the palatal mesenchyme with TGF-β treatment.
| TGF-β1 | TGF-β2 | TGF-β3 | ||||||
|---|---|---|---|---|---|---|---|---|
| TOP-10 UPREGULATED GENES | ||||||||
| Gene name | FC | p-Value | Gene name | FC | p-Value | Gene name | FC | p-Value |
| AMIGO2 | 22.89 | 4.88E-03 | AMIGO2 | 19.66 | 1.30E-05 | KIAA1654 | 1.56 | 2.18E-02 |
| NOX4 | 13.87 | 2.28E-02 | NOX4 | 11.12 | 2.72E-02 | NTM | 1.47 | 3.91E-02 |
| TNFAIP6 | 9.36 | 1.02E-02 | ANKRD1 | 10.33 | 2.38E-03 | LAMA1 | 1.46 | 3.58E-02 |
| DACT1 | 8.02 | 7.88E-03 | KCNH1 | 7.76 | 2.14E-02 | LRP11 | 1.41 | 3.78E-02 |
| ANKRD1 | 6.52 | 4.48E-02 | EDN1 | 6.48 | 1.65E-02 | |||
| PMEPA1 | 5.69 | 1.56E-03 | DACT1 | 6.47 | 2.54E-03 | Common upregulated | ||
| MSC | 5.55 | 2.01E-02 | PMEPA1 | 5.55 | 2.23E-02 | |||
| EDN1 | 5.23 | 1.44E-02 | HAPLN1 | 4.89 | 1.37E-02 | |||
| VDR | 5.19 | 1.36E-03 | VDR | 4.75 | 6.66E-04 | |||
| ITGB3 | 5.19 | 1.04E-02 | NEDD9 | 4.54 | 4.67E-03 | |||
| TOP-10 DOWNREGULATED GENES | ||||||||
| GDF5 | -4.08 | 2.07E-02 | TBC1D8 | -2.570 | 6.70E-03 | GEN1 | -1.40 | 2.75E-02 |
| >SECTM1 | -3.33 | 2.44E-02 | >SECTM1 | -2.540 | 4.37E-02 | POLK | -1.49 | 1.40E-02 |
| >NPTX1 | -3.25 | 1.61E-02 | >SMAD3 | -2.510 | 1.63E-02 | FLVCR2 | -1.52 | 4.42E-02 |
| >SMAD3 | -3.24 | 1.09E-02 | >OAS1 | -2.290 | 3.95E-02 | CPA4 | -1.70 | 1.40E-02 |
| >OAS1 | -3.11 | 2.27E-02 | ARHGAP28 | -2.230 | 4.42E-02 | |||
| >TBC1D8 | -3.06 | 4.50E-03 | >NPTX1 | -2.220 | 2.59E-02 | Common downregulated | ||
| TRERF1 | -2.75 | 3.35E-03 | >VSIG1 | -2.190 | 3.11E-02 | |||
| >VSIG1 | -2.75 | 3.00E-02 | HGF | -2.150 | 9.75E-03 | |||
| TGFBR3 | -2.62 | 2.82E-03 | NR4A2 | -2.020 | 4.56E-02 | |||
| CA12 | -2.59 | 7.71E-03 | IFIT2 | -1.970 | 3.39E-02 | |||
| GENES SUSCEPTIBLE FOR CRANIOFACIAL DEFORMITIES | ||||||||
| EDN1 | 5.23 | 1.44E-02 | EDN1 | 6.48 | 1.65E-02 | |||
| INHBA | 2.54 | 7.20E-03 | INHBA | 2.21 | 1.62E-02 | |||
| LHX8 | 1.62 | 1.84E-02 | LHX8 | NS | NS | |||
| PDGFC | 2.21 | 6.21E-03 | PDGFC | 2.06 | 5.95E-03 | |||
| PIGA | 1.51 | 1.71E-02 | PIGA | NS | NS | |||
| RUNX1 | 1.78 | 1.06E-03 | RUNX1 | 1.68 | 1.39E-03 | |||
| SMAD3 | −3.24 | 1.09E-02 | SMAD3 | −2.51 | 1.63E-02 | |||
| SNAI1 | 1.75 | 1.39E-02 | SNAI1 | 1.63 | 4.50E-02 | |||
| TGFβ1 | 1.91 | 3.26E-03 | TGFβ1 | 1.59 | 2.29E-03 | |||
| TGFβ2 | NS | NS | TGFβ2 | 1.78 | 4.22E-02 | |||
| TGFβR1 | 1.49 | 2.05E-02 | TGFβR1 | −1.81 | 7.33E-03 | |||
NS, Non-significant expression detected by dChip. Red (A): Genes upregulated in response to both TGFβ1 and TGFβ2. Green (B): Genes downregulated in response to both TGFβ1 and TGFβ2.