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. 2012 Feb 13;122(3):1010–1021. doi: 10.1172/JCI58431

Figure 1. Gross mapping of cis-regulatory elements for adipocyte-specific Lep gene expression using BAC transgenic mouse lines.

Figure 1

Top: Map of the Lep locus on mouse chromosome 6, showing areas of mouse-human conservation and regions covered by the 3 engineered BACs (M21, D7, and D4). Numbers refer to genomic coordinates for the beginning and end of each BAC, as well as the starting ATG of Lep (in exon 2) and the terminal GAA (in exon 3). There are no other known transcripts within this 300,000-bp region. Bottom: Maps of “trimmed” BACs. Numbers represent genomic coordinates of the ends of 4 new modified BACs, as well as exon 1, the terminal GAA in exon 3, and the transcriptional stop site.