Scheme 4.
Reagents and conditions: a) CDI, DMF then MeOH; b) N-Methylimidazole·HCl (4 equiv.), DMF/THF 1/1, rt, 12 h; c) 1 M LiOH·H2O, THF-MeOH-H2O (3:1:1), 54%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.