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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Circ Res. 2011 Mar 31;108(10):1226–1237. doi: 10.1161/CIRCRESAHA.110.239046

Figure 1. Cardiac function in the ISO injured heart.

Figure 1

Echocardiography (ECHO) was performed at Baseline, Day 7 (during injury), Day 10 (end of injury phase), Day 17 (early recovery) and Day 38 (late recovery). Representative ECHO data is shown in (A). B–D: Cardiac systolic and diastolic function was increasingly depressed from Baseline through Day 10 (N=19) and showed modest improvement after removal (at Day 10) of ISO minipumps by Day 17 (N=12) and at Day 38 (N=6). The transmitral E to A ratio was significantly depressed, indicating diastolic stiffening of the heart at Days 7 (N=15), 10 (N=17) and 17 (N=9), with modest recovery at Day 38 (N=6). *P<0.05; **P<0.01; ***P<0.001 versus Baseline. Data are presented as mean ± SEM.