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. Author manuscript; available in PMC: 2012 May 13.

Published in final edited form as: Circ Res. 2011 Mar 31;108(10):1226–1237. doi: 10.1161/CIRCRESAHA.110.239046

Cell loss, myocyte hypertrophy and replacement fibrosis can be seen in ISO-treated heart tissue. Collagen (Blue); cardiac tissue (Red). The percent blue area was quantified. The collagen content of the ventricles (C/D) and atria (E/F) increase after ISO injury: Masson’s Trichrome stained slides were used to measure changes in collagen content of all cardiac chambers. The assessment and analysis of the data was carried out in a blinded fashion. All chambers had significant increases in collagen content after ISO injury (Day 10), with small reductions during the next few weeks. Control-Day 10 (N=7); Day 17-Day 38 (N=6). *P<0.05; **P<0.01; ***P<0.001 versus Control. Data are presented as mean ± SEM.

Cell loss, myocyte hypertrophy and replacement fibrosis can be seen in ISO-treated heart tissue. Collagen (Blue); cardiac tissue (Red). The percent blue area was quantified. The collagen content of the ventricles (C/D) and atria (E/F) increase after ISO injury: Masson’s Trichrome stained slides were used to measure changes in collagen content of all cardiac chambers. The assessment and analysis of the data was carried out in a blinded fashion. All chambers had significant increases in collagen content after ISO injury (Day 10), with small reductions during the next few weeks. Control-Day 10 (N=7); Day 17-Day 38 (N=6). *P<0.05; **P<0.01; ***P<0.001 versus Control. Data are presented as mean ± SEM.