Figure 1.

Sweat gland innervation in control and diabetic subjects. A: In the skin of control subjects, distinct sweat glands (red) and characteristic periglandular innervation (dark blue) are noticeable. Sudomotor nerve fibers exhibit linear and dense immunoreactivities and form a reticulated pattern. B: In skin of diabetic subjects, only sparse and fragmented immunoreactive profiles (dark blue) surround sweat glands (red), reflecting nerve degeneration. Bar = 100 μm. (A high-quality digital representation of this figure is available in the online issue.)