Fig. 3.

Temporal expression profiles of selected genes following shear step-up. All expression values were normalized to the preconditioned value (time 0). In each panel, the first data point, immediately adjacent to the y-axis, represents the expression in static cultured endothelial cells obtained from the control set of experiments, also normalized to the preconditioned value. *P < 0.05, one-sample t-test against zero. ID1, ID2, ID3, inhibitors of DNA binding 1, 2, and 3; CXCR4, chemokine (C-X-C motif) receptor 4; KLF2 and KLF4, Kruppel-like factor 2 and 4; Ca²⁺-dependent K⁺ channel 4; HMOX1, heme oxygenase-1; eNOS, endothelial nitric oxide synthase.