Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2004 Mar;10(3):426–431. doi: 10.3201/eid1003.030878

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.

PMC Copyright notice

Ulcer on tongue of a prairie dog infected with monkeypox virus (A: hematoxylin and eosin stain, 12.5X original magnification). Orthopox viral antigens are abundant in the squamous epithelium, with lesser amounts in the ulcer bed (B: immunohistochemical stain using the anti-smallpox antibody, 12.5X original magnification). Tongue epithelial cell adjacent to epidermal basement membrane (small arrows) with Guarnieri-like inclusion (large arrow) (C: transmission electron microscopy, 2,400X original magnification). Higher magnification of the Guarnieri-like inclusion shows intracellular immature (arrowhead) and mature (arrows) orthopox virions. The mature virions consist of a dense core surrounded by several laminated zones and enclosed within an outer membrane. (D: transmission electron microscopy, 17,000X original magnification.)