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Putative model of CRL4Cdt2 recruitment to the PCNA·substrate complex. Substrate-dependent recruitment of CRL4Cdt2 to PCNADNA requires residues in the PIP degron (B+4), as well as PCNA Asp-122. PCNA Glu-124 also contributes to CRL4Cdt2 recruitment but is not essential. We speculate charged residues in Cdt2 make direct contacts with B+4, Asp-122, and Glu-124.
