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Model of HDAC6-mediated survivin deacetlyation for survivin nuclear export. ER+ breast cancer cells can be stimulated by estrogen that activates the histone acetyltransferase protein CBP. CBP induces HDAC6 expression and promotes its nuclear entry where it deacetylates survivin, independent of Crm1, and stimulates its nuclear export in a mechanism to control nuclear acetylated survivin levels.
