Table 1. Frequency of FGFR2 amplification in gastric cancers and its association with clinical and pathologic factors.
|
FGFR2 (+)
|
FGFR2 (−)
|
||||
|---|---|---|---|---|---|
| n=11 | % | n=256 | % | P-value | |
| Age | |||||
| Range | 55–91 | 31–88 | 0.047 | ||
| Median | 67 | 63 | |||
| Gender | |||||
| Male | 11 | 100 | 173 | 68 | 0.052 |
| Female | 0 | 0 | 83 | 32 | |
| Pstage | |||||
| I | 0 | 0 | 25 | 10 | 0.16a |
| II | 0 | 0 | 32 | 13 | |
| III | 3 | 27 | 73 | 29 | |
| IV | 8 | 73 | 125 | 49 | |
| Unknown | 0 | 0 | 1 | 0 | |
| Histology | |||||
| Tub1 | 0 | 0 | 41 | 16 | 0.55b |
| Tub2 | 2 | 18 | 51 | 20 | |
| Pap | 1 | 9 | 5 | 2 | |
| Muc | 2 | 18 | 8 | 3 | |
| Sig | 1 | 9 | 15 | 6 | |
| Por1 | 0 | 0 | 28 | 11 | |
| Por2 | 5 | 45 | 108 | 42 | |
Abbreviations: Amp=gene amplification; FGFR=fibroblast growth factor receptor; Muc=mucinous adenocarcinoma; Pap=papillary adenocarcinoma; Por=poorly differentiated adenocarcinoma; pStage=pathological stage; Sig=signet ring-cell carcinoma; Tub=tubular adenocarcinoma.
a
Comparison between pStage I+II and III+IV.
b
Comparison between intestinal (Tub1, Tub2 and Pap) and others. P-values were calculated using the t-test for age and the χ2 test for the other variables.