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. 2012 Jan 12;106(4):711–718. doi: 10.1038/bjc.2011.604

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Copyright © 2012 Cancer Research UK

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Effect of drug treatments on cell death morphology. (A(i)) Morphological features of KYSE450 cells treated with 5-FU (40 μM) alone (upper panels) or in combination with HA14-1 (20 μM) (lower panels) for 24 or 48 h. (B(i)) Morphological features of OE21 cells treated with 5-FU (30 μM) alone (upper panels) or in combination with HA14-1 (20 μM) (lower panels) for 24 or 48 h. Apoptosis and non-apoptotic/type II cell death are shown by arrows and arrowheads respectively ( × 40 magnification). The extent of type II (non-apoptotic) and apoptotic cell death in KYSE450 cells treated with 5-FU (40 μM) alone and in combination with HA14-1 (20 μM) for 48 h (A(ii)) and OE21 cells treated with 30 μM 5-FU alone and in combination with HA14-1 (20 μM) for 24 h (B(ii)) was determined by counting six fields of view per slide, with ∼350 cells per field ( × 10 magnification).