Table 5. Relationships between clinico-pathological factors and survival, in patients selected for potentially curative resection for oesophageal adenocarcinoma without neo-adjuvant therapy (n=53).

	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Patient-related factors
Age (<65/65 –74/⩾75 years)	2.07 (1.13–3.77)	0.018	2.62 (1.27–5.39)	0.009
Sex (male/female)	0.77 (0.27–2.21)	0.625
mGPS (0/1/2)	4.14 (1.80–9.51)	0.001	12.71 (4.15–38.94)	<0.001
Tumour-related factors
TNM stage (I/II/III)	2.46 (1.34–4.49)	0.004		0.246
Tumour differentiation (well-mod/poor)	2.35 (1.13–4.92)	0.023		0.552
Resection margin (R0/R1)	2.13 (1.02–4.49)	0.046		0.607
Positive to total lymph node ratio (0/⩽0.2/>0.2)	2.45 (1.55–3.89)	<0.001	3.18 (1.77–5.72)	<0.001
Adjuvant therapy (no/yes)	2.45 (0.83–7.22)	0.105
Klintrup–Makinen score (low/high grade)	0.28 (0.08–0.92)	0.036		0.055
Necrosis score (low/high grade)	1.29 (0.61–2.70)	0.505
CD8 tertiles	0.68 (0.43–1.10)	0.117
CD68 tertiles	1.49 (0.97–2.28)	0.066	1.88 (1.12–3.15)	0.017
Ki67 tertiles	1.35 (0.78–2.35)	0.289
CD34 tertiles	0.73 (0.45–1.20)	0.214

Abbreviations: CI=confidence interval; LNR=lymph node ratio; mGPS=modified Glasgow Prognostic score; TNM=tumour node metastasis.