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. 2012 Jan 31;106(4):685–692. doi: 10.1038/bjc.2012.6

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Copyright © 2012 Cancer Research UK

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.

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Effect of lovastatin and docetaxel on expression of genes involved in the initiation and progression of mitosis, cytokinesis, and MAP kinases signalling pathway. HGT-1 cells were treated with 12.5 μM lovastatin (L12.5) or with 5 or 10 nM docetaxel (D5 or D10) alone or in combination for 48 h. Cyclin D1, cyclin B1, aurora kinase A (A), aurora kinase B and survivin (B) mRNA levels were analysed by real-time RT–PCR. Relative mRNA levels were normalised to P0 mRNA levels. Values are means±s.d. (n=4). ^*Compared with control, #compared with docetaxel treatment, ^†compared with lovastatin treatment. One symbol: P<0.05, two symbols: P<0.01, three symbols: P<0.001 (Student's t-test). (C) Cyclin B1, cyclin D1, aurora kinase A, aurora kinase B, and survivin protein levels were analysed by western blotting. Hsc70 was used as a loading control. (D) phospho-JNK, phospho-MEK1/2, ERK1/2, phospho-ERK1/2, and p38 protein levels were analysed by western blotting. Hsc70 was used as a loading control. The western blotting analyses are representative of three experiments with similar results.