mGluR7 mediates l-AP4 reduction of NMDAR currents.
A, plot of normalized (Norm.) peak NMDAR currents in dissociated PFC pyramidal neurons showing the effect of l-AP4 (200 μm) in the absence or presence of group III mGluR antagonists CPPG (50 μm) or M-SOP (400 μm). ctl, control. B, cumulative data (mean ± S.E.) showing the percentage of reduction (% reduc.) of NMDAR currents by group III mGluR agonists l-AP4 or l-SOP (400 μm) in the absence (control) or presence of antagonists CPPG or M-SOP. *, p < 0.001, ANOVA, compared to the effects in the absence of the antagonists (−). C, plot of normalized peak NMDAR currents showing the effect of l-AP4 (200 μm) in cultured PFC pyramidal neurons transfected with or without mGluR7 siRNA.