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. 2012 Jan 27;287(13):10265–10275. doi: 10.1074/jbc.M111.325175

FIGURE 2.

FIGURE 2.

mGluR7 mediates l-AP4 reduction of NMDAR currents. A, plot of normalized (Norm.) peak NMDAR currents in dissociated PFC pyramidal neurons showing the effect of l-AP4 (200 μm) in the absence or presence of group III mGluR antagonists CPPG (50 μm) or M-SOP (400 μm). ctl, control. B, cumulative data (mean ± S.E.) showing the percentage of reduction (% reduc.) of NMDAR currents by group III mGluR agonists l-AP4 or l-SOP (400 μm) in the absence (control) or presence of antagonists CPPG or M-SOP. *, p < 0.001, ANOVA, compared to the effects in the absence of the antagonists (−). C, plot of normalized peak NMDAR currents showing the effect of l-AP4 (200 μm) in cultured PFC pyramidal neurons transfected with or without mGluR7 siRNA.