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. 2012 Jan 27;287(13):10265–10275. doi: 10.1074/jbc.M111.325175

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — β-Arrestin2 is involved in mGluR7 reduction of NMDAR currents and activation of ERK. A, plots of normalized (Norm.) peak NMDAR currents showing the effect of l-AP4 in cultured PFC neurons transfected without or with β-arrestin2 (β-arr2) siRNA. ctl, control. B, cumulative data (mean ± S.E.) showing the percentage of reduction (% reduc.) of NMDAR currents (curr.) by l-AP4 in cultures transfected with siRNA against β-arrestin1 or β-arrestin2. *, p < 0.001, ANOVA. C, Western blotting analysis showing the effect of l-AP4 on ERK activation (phosphorylation (p-ERK)) in cultured PFC neurons transfected without or with β-arrestin2 siRNA. *, p < 0.001, ANOVA.