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mGluR7 reduces NR1 binding to actin and PSD-95. A, co-immunoprecipitation (IP) and Western blot (WB) analysis showing the effect of l-AP4 treatment (200 μm, 10 min) on the interaction of NR1 with actin or PSD-95 in the absence or presence of mGluRIII antagonist CPPG (50 μm) or actin stabilizer phalloidin oleate (1 μm). B, cumulative data (mean ± S.E.) showing the effect of l-AP4 on NR1-actin binding or NR1-PSD-95 binding under different conditions. *, p < 0.001, ANOVA.
