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. 2012 Jan 27;287(13):10265–10275. doi: 10.1074/jbc.M111.325175

FIGURE 9.

FIGURE 9.

mGluR7 reduces level of surface NMDARs via actin-dependent mechanism. A, immunocytochemical staining of surface NR1 in PFC pyramidal neurons treated without (control) or with l-AP4 (200 μm, 10 min) in the absence or presence of actin stabilizer phalloidin oleate (1 μm, added 15 min prior to l-AP4 application). B, cumulative data (mean ± S.E.) showing the effect of l-AP4 on surface NR1 cluster density under different conditions. *, p < 0.001, ANOVA. C, Western blotting of surface or total NR1 from cultured PFC neurons treated without or with l-AP4 in the absence or presence of phalloidin oleate. D, cumulative data (mean ± S.E.) showing the effect of l-AP4 on the expression level of surface NR1 under different conditions. *, p < 0.001, ANOVA. Phall, phalloidin.