Table 2. Examples of inhibitory concentrations of antiviral drugs against selected virusesa.
Compound | IC50 | Virus |
---|---|---|
Foscavir |
50–800 μM |
Cytomegalovirus |
|
5–443 μM |
Herpes simplex mutants |
Acyclovir |
0.01–13.5 μg/ml |
Herpes smplex virus and varicella-zoster virus |
Cymevene |
0.02–3.48 μg/mL |
Laboratory strains or clinical isolates of cytomegalovirus |
Ribavirin |
1–25 μg/mL |
Influenza |
|
25–100 μg/mL |
HIV and other retroviruses |
|
3.2–50 μg/ml (MIC) |
Herpes and poxviruses suppression |
Lamivudine |
0.0006–0.034 μg/mL |
HIV |
Zidovudine |
0.003–0.013 μg/mL |
HIV |
Fortovase |
1–30 nM |
HIV |
Viracept |
7–196 nM (EC95) |
HIV |
Crixivan |
25–100 nM |
HIV |
Relenza |
0.005–16 μM |
Influenza virus |
Tamiflu |
0.0008 μM–>35 μM |
Influenza virus |
Amantadine | 0.1–25 (ED50) | Influenza virus |
aIC50, 50% inhibitory concentration; EC95, 95% effective concentration; ED50, 50% effective dose.