Figure 4.

Association of deiminated REF with protein translational machinery components. (A) Western analyses of antiREF (Refbp2) immunoprecipitation products with deiminated REF (d+) and control non-deiminated REF (d−) as bait. (B) Schematic diagram of REF mediate mRNA export at mitochondrial surface. The REF (indicated) exports polyadenylated cargo from the nucleus. REF becomes additionally deiminated (indicated as d+) by PAD2 and recruits members of protein translation initiation complex elf4F, facilitate the mRNA (ATP5b) transport to mitochondrial surface; details of REF interacting protein complex have been shown in the enlarged box. REF, RNA binding export factor.