Table 1. Kinases and phosphatases important for mitosis and their substrates.
| Kinase | Substrate (phosphosite) | Phosphatase | References |
|---|---|---|---|
| Cdk1–cyclin B | Broad range of substrates | PP2A-B55 | 15, 49, 64, 65, 66 |
| PP1 | 11, 67 | ||
| Cdc14 | 4 | ||
| NDEL1 (Thr 219*) | PP4 | 9 | |
| Fizzy/Cdc20 | PP2B/calcineurin | 12, 13 | |
| p90Rsk | Emi2 | PP2B/calcineurin | 12, 13 |
| Cdk2–cyclin E | Cdc25 (Thr 138#) | PP2A-B56 | 68 |
| Casein kinase 1 | Rec8 | PP2A-B56/Shugoshin | 5, 6, 7, 8 |
| Polo-like kinase 1 | Scc3/SA2 | PP2A-B56/Shugoshin | 5, 6, 7, 8 |
| Chk1 | Cdc25 (Ser 287#) | PP1 | 69, 70 |
| Aurora A | Aurora A (Thr 288 in T-loop*) | PP6-SAPs/ANKRDs | 71 |
| Aurora A and Aurora B | CENP-E (Thr 422*) | PP1 | 72 |
| Haspin | Histone H3 (Thr 3) | PP1γ-Repoman | 73 |
| Greatwall | α-Endosulfine/ARPP-19 (Ser 67#) | Unknown | 45, 46 |
| Wee1/Myt1 | Cdk1 (Thr 14/Tyr15) | Cdc25 | 74, 75 |
The number of each phosphosite shows its position either in
*human or in
#Xenopus protein.