Table 1. Deer tissues tested for the CWD agent by animal bioassay or immunohistochemical studiesa.
Tissues positive for CWD agent |
Brain |
Pituitary gland |
Spinal cord |
Eyes (optic nerve, ganglion cells, retina) |
Tonsils |
Lymphoid tissues (e.g., gut-associated, retropharyngeal, posterior nasal septum) |
Spleen |
Pancreas |
Peripheral nerves (e.g., brachial plexus, sciatic nerve, vagosympathetic trunk) |
Tissues negative for CWD agent |
Dorsal root ganglia |
Parotid and mandibular salivary glands, tongue, esophagus, small intestine, colon |
Thymus |
Liver |
Kidneys, urinary bladder, ovary, uterus, testis, epididymis, placentomes |
Myocardium, Purkinje fibers, arteries, veins |
Trachea, bronchi, bronchioles, aleveolar parenchyma |
Bone marrow |
Thyroid gland, adrenal gland |
Skeletal muscle |
Skin |
aCWD, chronic wasting disease.