. 2011 Jul 6;31(12):2313–2323. doi: 10.1038/jcbfm.2011.91

Table 3. Estimates of cerebral metabolic fluxes (μmol/g per min) during hyperketonemia and [2,4-¹³C₂]--BHB infusion determined by a constrained two-compartment (neuron–astrocyte) metabolic model.

	CMR_glc(ox)	CMR_kb	V_AcCoA-kbN	V_AcCoA-kbA	V_pdhA	V_pdhN	V_tcaN	V_tcaA	V_Gln	V_cyc
Mean	0.33	0.22	0.31	0.14	0.29	0.29	0.60	0.42	0.40	0.32
Group s.d.	(0.13)	(0.04)	(0.16)	(0.09)	0.08	0.18	(0.32)	(0.13)	(0.21)	(0.17)
MCSD	(0.03)	(0.01)	(0.02)	(0.02)	0.04	0.03	(0.05)	(0.05)	(0.03)	(0.02)

BHB, -β-hydroxybutyrate; MCSD, Monte-Carlo Standard Deviation.

Fluxes are given in units of μmol/g per min. Values represent mean±s.d. of six animals. The metabolic model was fitted to the time courses for each animal individually and the parameter estimates (best fits) were averaged to give the values shown. V_cyc/V_tcaN was constrained to the value of the ratio (0.54) calculated from Glu-C4 and Gln-C4 enrichments measured at isotopic steady-state during an infusion of [2-¹³C]acetate for a separate group of 36 hour-fasted rats (see the ‘Materials and methods' section). V_pc was constrained to 0.2 × V_gln (Sibson et al, 2001). MCSD is the mean s.d. from the 20-step Monte Carlo analysis of 6 animals, providing a measure of the quality of individual fits.

Table 3. Estimates of cerebral metabolic fluxes (μmol/g per min) during hyperketonemia and [2,4-13C2]--BHB infusion determined by a constrained two-compartment (neuron–astrocyte) metabolic model.

Table 3. Estimates of cerebral metabolic fluxes (μmol/g per min) during hyperketonemia and [2,4-¹³C₂]--BHB infusion determined by a constrained two-compartment (neuron–astrocyte) metabolic model.