Figure 4.
P-glycoprotein (P-gp) but not endothelial barrier antigen (EBA) is uniformly expressed among endothelial cells within the capillary bed. Distributions of fluorescence intensity in capillaries crosssections after laminin, caveolin-1 (cav-1), P-gp, or EBA immunostaining. The measured distributions are well fitted by a normal (P-gp) or a log-normal (laminin, cav-1) distribution, except for EBA whose distribution is monotonically decreasing. Data are pooled from three rats in three independent experiments, giving a total of 430 (laminin), 1158 (cav-1), 420 (P-gp), and 1552 (EBA) crosssections in the cortex and the CA1 region of the hippocampus.