TABLE 2. Mean peak subjective effects during marijuana administration (3.3% THC) and during abstinence as a function of baclofen dose.
Baclofen Dose (mg) | |||
---|---|---|---|
0 | 60 | 90 | |
High Cluster | |||
3.3% THC | 61 (9) | ↓44 (10)* | 57 (8) |
0.0% THC | ↓4 (1)## | 5 (3) | 5 (9) |
Irritable Cluster | |||
3.3% THC | 9 (4) | 4 (2) | 8 (5) |
0.0% THC | 22 (8) | 17 (5) | 11 (5) |
Anxious Cluster | |||
3.3% THC | 11 (5) | 7 (3) | 13 (5) |
0.0% THC | 11 (3) | 9 (2) | 9 (3) |
Social Cluster | |||
3.3% THC | 55 (5) | 54 (6) | 51 (6) |
0.0% THC | ↓46 (7)# | 49 (6) | 49 (6) |
Confused Cluster | |||
3.3% THC | 20 (11) | 10 (6) | 17 (7) |
0.0% THC | ↓9 (7)# | 5 (2) | 7 (3) |
Tired Cluster | |||
3.3% THC | 27 (8) | 23 (6) | 32 (6) |
0.0% THC | 23 (6) | 23 (4) | 22 (5) |
| |||
Eating Occasions (#/day) | |||
3.3% THC | 10.5 (0.9) | 10.2 (1.1) | 10.1 (1.0) |
0.0% THC | ↓6.4 (0.5)# | 6.7 (0.5) | 6.3 (0.7) |
Note Data in parentheses represent standard error of the mean; maximum mood score = 100 mm. Asterisks represent significant differences from placebo baclofen
p <0.05,
p <0.01, and the adjacent arrow signs indicate the direction of the significant effect. Number signs represent significant differences between active marijuana administration and marijuana abstinence under placebo baclofen conditions
p <0.05,
p <0.01, and the adjacent arrow signs indicate the direction of the significant effect.