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. Author manuscript; available in PMC: 2012 Apr 10.
Published in final edited form as: Psychopharmacology (Berl). 2010 Jun 3;211(2):233–244. doi: 10.1007/s00213-010-1888-6

TABLE 2. Mean peak subjective effects during marijuana administration (3.3% THC) and during abstinence as a function of baclofen dose.

Baclofen Dose (mg)
0 60 90
High Cluster
3.3% THC 61 (9) ↓44 (10)* 57 (8)
0.0% THC ↓4 (1)## 5 (3) 5 (9)
Irritable Cluster
3.3% THC 9 (4) 4 (2) 8 (5)
0.0% THC 22 (8) 17 (5) 11 (5)
Anxious Cluster
3.3% THC 11 (5) 7 (3) 13 (5)
0.0% THC 11 (3) 9 (2) 9 (3)
Social Cluster
3.3% THC 55 (5) 54 (6) 51 (6)
0.0% THC ↓46 (7)# 49 (6) 49 (6)
Confused Cluster
3.3% THC 20 (11) 10 (6) 17 (7)
0.0% THC ↓9 (7)# 5 (2) 7 (3)
Tired Cluster
3.3% THC 27 (8) 23 (6) 32 (6)
0.0% THC 23 (6) 23 (4) 22 (5)

Eating Occasions (#/day)
3.3% THC 10.5 (0.9) 10.2 (1.1) 10.1 (1.0)
0.0% THC ↓6.4 (0.5)# 6.7 (0.5) 6.3 (0.7)

Note Data in parentheses represent standard error of the mean; maximum mood score = 100 mm. Asterisks represent significant differences from placebo baclofen

*

p <0.05,

**

p <0.01, and the adjacent arrow signs indicate the direction of the significant effect. Number signs represent significant differences between active marijuana administration and marijuana abstinence under placebo baclofen conditions

#

p <0.05,

##

p <0.01, and the adjacent arrow signs indicate the direction of the significant effect.