TABLE 3. Mean peak effects during marijuana administration (6.2% THC) and during abstinence as a function of mirtazapine dose.
| Mirtazapine Dose (mg) | ||
|---|---|---|
| 0 | 30 | |
| High Cluster | ||
| 6.2% THC | 68 (7) | 78 (7) |
| 0.0% THC | ↓4 (2)## | 4 (4) |
| Irritable Cluster | ||
| 6.2%THC | 9 (5) | 15 (8) |
| 0.0% THC | ↑31 (12)## | 38 (11) |
| Anxious Cluster | ||
| 6.2%THC | 8 (2) | 14 (4) |
| 0.0% THC | ↑17 (6) ## | 26 (8) |
| Social Cluster | ||
| 6.2%THC | 58 (8) | 61 (7) |
| 0.0% THC | ↓50 (8)# | 47 (7) |
| Confused Cluster | ||
| 6.2%THC | 8 (2) | 9 (3) |
| 0.0% THC | ↑17 (6)# | 19 (6) |
| Tired Cluster | ||
| 6.2% THC | 32 (5) | 31 (5) |
| 0.0% THC | ↑41 (7)# | 36 (7) |
|
| ||
| Eating Occasions (#/day) | ||
| 6.2% THC | 11.4 (0.7) | ↑14.5 (0.8)** |
| 0.0% THC | ↓5.6 (0.9) ## | ↑7.5 (0.9)** |
Note Data in parentheses represent standard error of the mean; maximum mood score = 100 mm. Asterisks represent significant differences from placebo mirtazapine
*
p <0.05,
**
p <0.01. Number signs represent significant differences between active marijuana administration and marijuana abstinence under placebo mirtazapine conditions
#
p <0.05,
##
p <0.01.