Figure A3.

A structure-based sequence alignment of the influenza A virus hemagglutinin precursor protein from human A/Canada/504/04 (Hu504) with that of the hemagglutinin precursor protein (HA0) from influenza A virus, human strain CV-1 whose structure was solved by Wiley and colleagues in 1998 (PDBcode 1HAO) (22). The alignment shows 49.9% identity in sequence. Insertions and deletions are highlighted in grey and nonconservative mutations are shown in yellow. Conserved cysteines are boxed. The glycosylated aparagines which are conserved are boxed with thin lines; the glycosylated asparagines that are not conserved are boxed with thick lines.